Yoshihiro_Takai_5.jpg

高井 良寻

南东北硼中子俘获疗法研究中心主任

  • 现职

    • 南东北硼中子俘获疗法研究中心主任
    • 弘前大学医学部名誉教授

  • 学历

    • 1976

      福岛县立医科大学医学部医学士

    • 1983

      东京大学医学系研究科放射线基础医学博士

  • 专科医师资格

    • 日本放射线医学会专家及放射线治疗认证指导医师
    • 日本环境省原子力规制委员会第一种辐射防护证照督导

  • 经历

    • 1976-1977

      东京大学医学部放射线学科讲师

    • 1977-1979

      东京大学医学部放射线学与生物医学工程学科讲师

    • 1983-1984

      东北大学医学部放射线学科讲师

    • 1986-1996

      东北大学医学部放射线学科资深讲师

    • 1996-2005

      东北大学医学部放射线学科副教授

    • 2005-2008

      东北大学医学部保健学科临床放射技术学教授

    • 2008-2010

      东北大学医学系研究科保健学科放射治疗学教授

    • 2010-2016

      弘前大学大学院医学研究科放射线学科与放射肿瘤学科教授及主任

    • 2006-至今

      南东北硼中子俘获疗法研究中心主任

  • 专长

    • 恶性（癌）肿瘤放射治疗
    • 硼中子俘获疗法
    • 放射肿瘤学
    • 放射生物学

  • 医学会

    • 1993-1996

      日本放射线医学会肿瘤学委员会委员

    • 1996-1997

      日本放射线医学会教育委员会委员及健康保险委员会委员

    • 2000-2016

      日本放射线医学会代表

    • 2004-2007

      日本食道学会评议员

    • 2007-2014

      日本放射肿瘤学会理事

    • 2007-2010

      日本放射肿瘤学会病患安全委员会委员长及调查研究委员会委员长

    • 2012-2014

      日本放射肿瘤学会编辑委员会委员长

    • 2013年10月18日至20日

      第26届日本放射肿瘤学会学术年会主席 (日本青森)

    • 2014年11月4日至7日

      日本教育文化体育科技省2014亚洲核能论坛协调者

    • 2017年9月29日至30日

      第14届日本中子俘获疗法学会学术年会主席 (日本郡山)

  • 精选学术论文

    • Masahiko Aoki, Mariko Sato, Katsumi Hirose, Hiroyoshi Akimoto, Hideo Kawaguchi, Yoshiomi Hatayama, Shuichi Ono, Yoshihiro Takai, Radiation-induced rib fracture after stereotactic body radiotherapy with a total dose of 54-56 Gy given in 9-7 fractions for patients with peripheral lung tumor: impact of maximum dose and fraction size.  Radiation oncology (London, England) 2015; 10: 99-1-99-8
    • Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Yoshihiro Takai, Makoto Yoshizawa Tracking tumor boundary in MV-EPID images without implanted markers: A feasibility study.  Medical physics  2015; 42 (5): 2510-2510
    • Takaaki Beppu, Toshiaki Sasaki, Kazunori Terasaki, Hiroaki Saura, Hideki Mtsuura, Kuniaki Ogasawara, Makoto Sasaki, Shigeru Ehara, Ren Iwata, Yoshihiro Takai, High-uptake areas on positron emission tomography with the hypoxic radiotracer (18)F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia. Annals of Nuclear Medicine 2015; 29:336-341
    • Hiroaki Saura, Kuniaki Ogasawara, Takaaki Beppu, Koji Yoshida, Masakazu Kobayashi, Kenji Yoshida, Kazunori Terasaki, Yoshihiro Takai, Akira Ogawa, Hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery stenoocclusive disease.  Stroke 2015; 46:1250-1256
    • Mariko Sato, Katsumi Hirose, Ikuo Kashiwakura, Masahiko Aoki, Hideo Kawaguchi, Yoshiomi Hatayama, Hiroyoshi Akimoto, Yuichiro Narita, Yoshihiro Takai, LW6, a hypoxia inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Molecular medicine reports 2015; 12: 3462-3468
    • K Hirose, M Sato, M Aoki, H Kawaguchi, H Akimoto, Y Hatayama, F Komai, M Sohma, H Obara, M Suzuki, Y Takai, SU-E-J-40: Improving Uncertainty of Prostate Positioning by Using Implanted Fiducial Marker-Based Hybrid Evaluation Combined with KV Portal Imaging and CBCT for Prostate IMRT. Medical physics 2015; 42 (6): 3272-3272
    • X Zhang, N Homma, Y Takai, K Ichiji, N Sugita, M Abe, M Yoshizawa, WE-AB-303-02: A Real-Time Homography-Based Algorithm for Markerless Deformable Lung Tumor Motion Tracking Using KV X-Ray Fluoroscopy. Medical physics 2015; 42 (6): 3656-3656
    • Y. Hatayama, T. Nakamura, M. Suzuki, Y. Azami, T. Ono, H. Yamaguchi, Y. Hayashi, I. Tsukiyama, M. Hareyama, Y. Kikuchi, Y. Takai, Preliminary results of proton-beam therapy for stage III non-small-cell lung cancer Current Oncology. 2015; 22(5): e370-5
    • Hatayama Y, Nakamura T, Suzuki M, Azami Y, Ono T, Yabuuchi T, Hayashi Y, Kimura K, Hirose K, Wada H, Hareyama M, Kikuchi Y, Takai Y. Clinical Outcomes and Prognostic Factors of High-Dose Proton Beam Therapy for Peripheral Stage I Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2015; pii: S1525-7304(15)00277-6.
    • Aoki M, Hatayama Y, Kawaguchi H, Hirose K, Sato M, Akimoto H, Fujioka I, Ono S, Takai Y, Stereotactic body radiotherapy for lung metastases as oligo-recurrence: A single institutional study J Radiat Res 2016; 57:55-61
    • Aoki M, Hatayama Y, Kawaguchi H, Hirose K, Sato M, Akimoto H, Fujioka I, Ono S, Tsushima E, Takai Y., Clinical outcome of stereotactic body radiotherapy for primary and oligometastatic lung tumors: a single institutional study with almost uniform dose with different five treatment schedules. Radiat Oncol. 2016; 20:11(1):5
    • Aoki M, Hirose K, Sato M, Akimoto H, Kawaguchi H, Hatayama Y, Fujioka I, Tanaka M, Ono S, Takai Y., Prognostic impact of average iodine density assessed by dual-energy spectral imaging for predicting lung tumor recurrence after stereotactic body radiotherapy. J Radiat Res. 2016; pii: rrv100.
    • Wada Y, Hirose K, Harada T, Sato M, Watanabe T, Anbai A, Hashimoto M, Takai Y. Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy. J Radiat Res. 2018; 59:122-128.
    • Hirose K, Sato M, Hatayama Y, Kawaguchi H, Komai F, Sohma M, Obara H, Suzuki M, Tanaka M, Fujioka I, Ichise K, Takai Y, Aoki M., The potential failure risk of the cone-beam computed tomography-based planning target volume margin definition for prostate image-guided radiotherapy based on a prospective single-institutional hybrid analysis. Radiat Oncol. 2018 Jun 7;13(1):106. doi: 10.1186/s13014-018-1043-9.
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