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Hiroshi Terunuma, M.D., Ph.D.

Medical Oncologist
Deputy Superintendent, Tokyo Clinic

  • Present Title & Affiliation

    • Deputy Superintendent, Tokyo Clinic, Japan
    • Director, Regenerative Factor Clinical Study Center, Southern TOHOKU Research Institute for Neuroscience, Japan

  • Education

    • 1985 M.D.

      Tohoku University School of Medicine, Japan

    • 1989 Ph.D.

      Dept. of Pathology, Tohoku University Graduate School of Medicine, Japan

  • Certifications

    • 2004

      Board-certified Internal Medicine physician, The Japanese Society of Internal Medicine

    • 2011

      Board-certified Clinical Supervisor, Japanese Society for Thermal Medicine

    • 2015

      Board-certified physician, The Japanese Society for Regenerative Medicine

  • Professional Experience

    • 1989-1990

      Lecturer, Dept. of Neurological Sciences, Tohoku University School of Medicine, Japan

    • 1990-1992

      Visiting Researcher, The Wistar Institute, Philadelphia, USA

    • 1993-1995

      Lecturer (Research), Dept. of Medicine, The University of Miami Miller School of Medicine, USA

    • 1993-1995

      Lecturer, Dept. of Neurological Sciences, Tohoku University School of Medicine, Japan

    • 1995-1997

      Long-term Expert (Medicine), The project for infectious disease control in the Republic of Zambia, Japan International Cooperation Agency (JICA)

    • 1997-2004

      Senior Lecturer, Dept. of Microbiology, University of Yamanashi Faculty of Medicine, Japan

    • 2004-present

      Director, Biotherapy Institute of Japan Co. Ltd., Japan

    • 2007-present

      Deputy Superintendent, Tokyo Clinic, Japan

    • 2007-present

      Director, Center for Immunotherapy and Hyperthermia, Southern TOHOKU General Hospital, Japan

    • 2014-present

      Director, Regenerative Factor Clinical Study Center, Southern TOHOKU Research Institute for Neuroscience, Japan

  • Skill Highlights

    • Cancer immunotherapy
    • Hyperthermia
    • Regenerative Medicine

  • Professional Memberships

    • The Japanese Society of Internal Medicine
    • Japanese Society for Thermal Medicine
    • The Japanese Society for Regenerative Medicine
    • Japanese Cancer Association
    • Japan Society of Clinical Oncology
    • Japanese Association of Cancer Immunology
    • Japan Society for Biological Therapy
    • Japanese Society for Immunology
    • The Japanese Society of Inflammation and Regeneration
    • Japan Clinical Health Care and Welfare
    • The Society for Integrative Medicine Japan

  • Selected Publications

    • Terunuma A, Ashiba K, Takane T, Sakaguchi Y, Terunuma H: Comparative transcriptomic analysis of human mesenchymal stem cells derived from dental pulp and adipose tissues. J Stem Cells Regenerative Med 15: 1-4, 2019
    • Mizutani M, Terunuma H, Samejima H, Ashiba K, Kino-oka M: Variation in the manufacturing reproducibility of autologous cell-based products depending on raw material shipment conditions. Regenerative Therapy, 12: 102-107, 2019
    • Eiraku Y, Terunuma H, Yagi M, Deng X, Nicol AJ, Nieda M: Dendritic cells cross-talk with tumour antigen-specific CD8+T cells, Vγ9γδT cells and Vα24NKT cells in patients with glioblastoma multiforme and in healthy donors. Clinical and Experimental Immunology 194: 54-66, 2018
    • Yagi M, Terunuma H, Eiraku Y, Deng X, Nieda M: Induction of Cytomegalovirus pp65-specific CD8+T Cells in vivo Following Administration of Autologous Tumorlysate-pulsed Dendritic Cells, Coplused with Zoledronate and α-Galactosylceramide in a Patient with Glioblastoma multiforme. Clinical Research in Immunology, 1: 1-5, 2018
    • Terunuma H, Ashiba K, Terunuma A, Deng X, Watanabe K: Conditioned medium of human immortalized mesenchymal stem cells as a novel therapeutic tool to repair damaged tissues. J Neuroscience Neuroengineering 4: 9-12, 2017
    • Preethy S, Dedeepiya VD, Senthilkumar R, Rajmohan M, Karthick R, Terunuma H, Abraham SJK.: Natural killer cells as a promising tool to tackle cancer – A review of sources, methodologies, and potentials. Int Rev Immunol 36: 220-232, 2017
    • Chidambaram R, Terunuma H, Balamurugan M, Dedeepiya VD, Sumana P, Senthilkumar R, Rajmohan M, Karthick R, Preethy S, Abraham SJK.: Cell-based immunotherapy in stage IIIA inflammatory breast cancer with declining innate immunity following successive chemotherapies: A case report. Molecular Clinical Oncology 7: 493-497, 2017
    • Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ: Dendritic Cells Cross Talk with Cytomegalovirus pp65-Specific Cytotoxic T Cells, Vγ9γδT Cells, and Invariant NKT Cells in Patients with Glioblastoma Multiforme. In: Hiroto S. Watanabe, editor. Horizons in Cancer Research, volume 63. New York, Nova Science Publisher, Inc.; pp93-118, 2016
    • Mizutani M, Samejima H, Terunuma H, Kino-oka M: Experience of contamination during autologous cell manufacturing in cell processing facility under the Japanese Medical Practitioners Act and the Medical Care Act. Regenerative Therapy 5: 25-30, 2016
    • Terunuma H: Potentiating Immune System by Hyperthermia. In: Kokura S, Yoshikawa T, Ohnishi T, editors. Hyperthermic oncology from bench to bedside. Singapore, Springer Singapore; pp127-135, 2016
    • Terunuma H, Nishino N, Abe T, Yoshimura A, Toki A, Ishiguro T, Deng X, Terunuma A: Combining Hyperthermia and Immunotherapy: NK Therapy and Hyperthermia. In: Kokura S, Yoshikawa T, Ohnishi T, editors. Hyperthermic oncology from bench to bedside. Singapore, Springer Singapore; pp309-318, 2016
    • Terunuma H, Ashiba K, Deng X, Shigeno J, Takane T, Samejima H, Terunuma A): Generating large numbers of activated natural killer (NK) cells and their utility in cancer therapy). BIO Clinica 31: 55-61, 2016 [Japanese].
    • Abraham SJK, Terunuma H, Dedeepiya VD, Premkumar S, Preethy S: An overview of treatment for cervical cancer with emphasis on immune cell-based therapies. In: de Mello RA, Tavares A, Mountzios G, editors. International Manual on Oncology Practice. London, Springer International Publishing AG Switzerland, Inc.; pp933-954, 2015
    • Sakurai D, Iwatani Y, Ohtani H, Naruse KT, Terunuma H, Sugiura W, Kimura A: APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese. Immunogenetics 67: 253-257, 2015
    • Ashiba K, Terunuma A, Terunuma H, Takane T, Deng X, Yamashita Y, Watanabe K: Immortalized mesenchymal stem cells producing conditioned medium in a large scale for therapeutic usage. Inflammation Regeneration 35, 2015
    • Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ: Preferential expansion of Th1 type-CD56+ Vγ9γδT cells by CD56high+IFNα-induced dendritic cells derived from cancer patients in vitro and in vivo. Int J Immunol Immunother 2, 1-8, 2015
    • Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ: Effective induction of melanoma-antigen-specific CD8+ T cells via Vγ9γδT cell expansion by CD56high+ interferon- a -induced dendritic cells. Experiment Dermatol 24, 35-41, 2015
    • Deng X, Terunuma H, Terunuma A, Takane T, Nieda M: Ex vivo- expanded natural killer cells kill cancer cells more effectively than ex vivo-expandedγδ T cells or αβ T cells. Int Immunopharmacol 22: 486-491, 2014
    • Osawa H, Orii K, Terunuma H, Abraham SJK: Combining autologous peripheral blood mononuclear cells with fibroblast growth factor therapy along with stringent infection control leading to successful limb salvage in diabetic patient with chronic renal failure and severe toe gangrene. Int J Stem Cells 7: 158-161, 2014
    • Bhamare S, Prabhakar P, Dharmadhikari A, Dedeepiva VD, Terunuma H, Senthilkumar R, Srinivasan T, Reena HC, Abraham SJ: Autologous immune enhancement therapy in a case of gall bladder cancer stage IV after surgical resection and chemotherapy yielding a stable non-progressive disease. J Cancer Res Ther 10: 752-754, 2014
    • Raj R, Deenadayalan M, Kumar GV, Khandelwal V, Sri K, Senthilkumar R, Abraham SJK, Terunuma H: Autologous immune enhancement therapy in Philadelphia chromosome-positive acute lymphoblastic leukemia. Indian J Hematol Blood Transfus, Issue 1 supplement 30: 202-204, 2014
    • Subramani B, Pullai CR, Krishnan K, Sugadan SD, Deng X, Terunuma H, Ratnavelu K: Efficacy of ex vivo activated and expanded natural killer cells and T lymphocytes for colorectal cancer patients. Biomed Reports 2: 505-508, 2014
    • Subramani B, Ratnavelu K, Pullai CR, Krishnan K, Sugadan SD, Deng X, Terunuma H: Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncol Lett 5: 1611-1614, 2013
    • Ratnavelu K, Subramani B, Pullai CR, Krishnan K, Sugadan SD, Rao MS, Veerakumarasivam A, Deng X, Terunuma H: Autologous immune enhancement therapy against an advanced epithelioid sarcoma: A case report. Oncol Lett 5: 1457-1460, 2013
    • Terunuma H, Deng X, Nishino N, Watanabe K: NK cell-based autologous immune enhancement therapy (AIET) for cancer. J Stem Cells Regenerative Med 9: 9-13, 2013
    • Nakayama EE, Nakajima T, Kaur G, Mimaya J, Terunuma H, Mehra N, Kimura A, Shioda T: A naturally occurring single amino acid substitution in human TRIM5a linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection. AIDS Research Hum Retroviruses 29: 919-924, 2013
    • Preethy S, John S, Ganesh SJ, Srinivasan T, Terunuma H, Iwasaki M, Abraham SJK: Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives. Stem cells and Cloning: Advances and Applications 6: 13-18, 2013
    • Premkumar S, Dedeepiya VD, Terunuma H, Senthilkumar R, Srinivasan T, Reena HC, Preethy S, Abraham SJK: Cell based autologous immune enhancement therapy (AIET) after radiotherapy in a locally advanced carcinoma of the cervix. Case Reports in Oncological Medicine Article ID 903094, http://dx.doi.org/10.1155/2013/903094, 2013
    • Deng X, Terunuma H, Nieda M, Xiao W, Nicol A: Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells. Int Immunopharmacol 14: 593-605, 2012
    • Terunuma H, Deng X, Toki A, Yoshimura A, Nishino N, Takano Y, Nieda M, Sasanuma J, Teranishi Y, Watanabe K: Effects of hyperthermia on the host immune system: from NK cell-based science to clinical application. Thermal Med 28: 1-9, 2012
    • Manjunath SR, Ramanan G, Dedeepiya VD, Terunuma H, Deng X, Baskar S, Senthilkumar R, Thamaraikannan P, Srinivasan T, Preethy S, Abraham SJK: Autologous immune enhancement therapy in recurrent ovarian cancer with metastases: a case report. Case Reports in Oncology 5: 114-118, 2012
    • Dedeepiya VD, Terunuma H, Deng X, Baskar S, Manjunath SR, Senthilkumar R, Murugan P, Thamaraikannan P, Srinivasan T, Preethy S, Abraham SJK: A comparative analysis of in vitro expansion of natural killer cells of a patient with autoimmune haemolytic anemia and ovarian cancer with patients with other solid tumours. Oncol letters 3: 435-440, 2012. PMID: 22740927
    • Takada M, Terunuma H, Deng X, Dewan MZ, Saji S, Kuroi K, Yamamoto N, Toi M: Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach. Breast Cancer 18: 64-67, 2011
    • Itaya S, Nakajima T, Kaur G, Terunuma H, Ohatani H, Mehra N, Kimura A: No evidence for the association of APOBEC3B deletion polymorphism with the susceptibility to HIV/AIDS in Japanese and Indian populations. J Infect Dis 202: 815-816, 2010
    • Nakajima T, Nakayama EE, Kaur G, Terunuma H, Mimaya JI, Ohtani H, Mehra N, Shioda T, Kimura A: Impact of novel TRIM5α variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS 23: 2091-2100, 2009
    • Dewan MZ, Takada M, Terunuma H, Deng X, Ahmed S, Yamamoto N, Toi M: Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients. Biomed Pharmacother 63: 703-706, 2009
    • Terunuma H, Deng X, Dewan Z, Fujimoto S, Yamamoto N: Potential role of NK cells in the induction of immune responses: Implications for NK cell-based immunotherapy for cancers and viral infections. Int Rev Immunol 27: 93-110, 2008
    • Nakajima T, Ohtani H, Naruse T, Shibata H, Mimaya JI, Terunuma H, Kimura A: Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia. Immunogenetics 59: 793-798, 2007
    • Terunuma H, Wada A, Deng X, Yasuma Y, Onishi T, Toki A, Abe H: Mild hyperthermia modulates the relative frequency of lymphocyte cell subpopulations: an increase in a cytolytic NK cell subset and a decrease in a regulatory T cell subset. Thermal Medicine 23: 41-47, 2007
    • Dewan MZ, Terunuma H, Takada M, Tanaka Y, Abe H, Sata T, Toi M, Yamamoto N: Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo. Breast Cancer Res Treat 104: 267-275, 2007
    • Hoshino S, Sun B, Konishi M, Shimura M, Segawa T, Hagiwara Y, Koyanagi Y, Iwamoto A, Mimaya J, Terunuma H, Kano S, Ishizaka Y: Vpr in plasma of HIV-1-positive patients is correlated with the HIV-1 RNA titers. AIDS Research Hum Retroviruses 23: 391-397, 2007
    • Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N: Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. Cancer Sci 97: 1381-1387, 2006
    • Dewan MD, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M, Yamamoto N: Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomedicine & Pharmacotherapy 59: S375-S379, 2005.

     

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