Yoshihiro Takai, M.D., Ph.D.
Radiation OncologistDirector, Southern TOHOKU BNCT Research Center
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Present Title & Affiliation
- Director, Southern TOHOKU BNCT Research Center
- Professor Emeritus, Hirosaki University School of Medicine, Japan
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Education
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1976 M.D.
School of Medicine, Fukushima Medical University, Japan
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1983 Ph.D.
Dept. of Radiation Biophysics, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan
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Certifications
- Specialist and board-certified Radiology instructor by Japan Radiological Society (JRS)
- Radiation Protection Supervisor (Category I), the Nuclear Regulation Authority (NRA), Ministry of the Environment, Japan
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Professional Experience
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1976-1977
Lecturer, Dept. of Radiology, Faculty of Medicine, The University of Tokyo, Japan
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1977-1979
Lecturer, Dept. of Radiation Biophysics, Faculty of Medicine, The University of Tokyo, Japan
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1983-1984
Lecturer, Dept. of Radiology, Tohoku University School of Medicine, Japan
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1986-1996
Senior Lecturer, Dept. of Radiology, Tohoku University School of Medicine, Japan
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1996-2005
Associate Professor, Dept. of Radiology, Tohoku University School of Medicine, Japan
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2005-2008
Professor, Clinical Radiation Technology Course, Tohoku University School of Health Sciences, Tohoku University School of Medicine, Japan
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2008-2010
Professor, Dept. Therapeutic Radiology, Tohoku University Graduate School of Health Sciences, Japan
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2010-2016
Professor and Director, Dept. of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Japan
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2016-present
Director, Southern TOHOKU BNCT Research Center, Japan
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Skill Highlights
- Radiation therapy for malignant (cancerous) tumors
- Boron Neutron Capture Therapy (BNCT)
- Radiation oncology
- Radiation biology
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Professional Memberships
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1993-1996
Member, Oncology Committee, Japanese Radiological Society (JRS)
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1996-1997
Committee members of Education Committee & Health Insurance Committee, Japanese Radiological Society (JRS)
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2000-2016
Representative, Japanese Radiological Society (JRS)
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2004-2007
Councilor, The Japan Esophageal Society
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2007-2014
Board Member, Japanese Society for Radiation Oncology (JASTRO)
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2007-2010
Committee Chair of Patient Safety Committee & Survey and Research Committee, Japanese Society for Radiation Oncology (JASTRO)
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2012-2014
Chair, Editorial Committee, Japanese Society for Radiation Oncology (JASTRO)
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Oct. 18-20, 2013
Meeting Chairman, The 26th Annual Meeting of Japanese Society for Radiation Oncology (JASTRO) (Aomori, Japan)
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Nov. 4-7, 2014
Coordinator, 2014 Forum for Nuclear Cooperation in Asia (FNCA), Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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Sep. 29-30, 2017
Meeting Chairman, The 14th Congress on Neutron Capture Therapy (Koriyama, Japan)
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Selected Publications
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Masahiko Aoki, Mariko Sato, Katsumi Hirose, Hiroyoshi Akimoto, Hideo Kawaguchi, Yoshiomi Hatayama, Shuichi Ono, Yoshihiro Takai, Radiation-induced rib fracture after stereotactic body radiotherapy with a total dose of 54-56 Gy given in 9-7 fractions for patients with peripheral lung tumor: impact of maximum dose and fraction size. Radiation oncology (London, England) 2015; 10: 99-1-99-8
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Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Yoshihiro Takai, Makoto Yoshizawa Tracking tumor boundary in MV-EPID images without implanted markers: A feasibility study. Medical physics 2015; 42 (5): 2510-2510
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Takaaki Beppu, Toshiaki Sasaki, Kazunori Terasaki, Hiroaki Saura, Hideki Mtsuura, Kuniaki Ogasawara, Makoto Sasaki, Shigeru Ehara, Ren Iwata, Yoshihiro Takai, High-uptake areas on positron emission tomography with the hypoxic radiotracer (18)F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia. Annals of Nuclear Medicine 2015; 29:336-341
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Hiroaki Saura, Kuniaki Ogasawara, Takaaki Beppu, Koji Yoshida, Masakazu Kobayashi, Kenji Yoshida, Kazunori Terasaki, Yoshihiro Takai, Akira Ogawa, Hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery stenoocclusive disease. Stroke 2015; 46:1250-1256
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Mariko Sato, Katsumi Hirose, Ikuo Kashiwakura, Masahiko Aoki, Hideo Kawaguchi, Yoshiomi Hatayama, Hiroyoshi Akimoto, Yuichiro Narita, Yoshihiro Takai, LW6, a hypoxia inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells. Molecular medicine reports 2015; 12: 3462-3468
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K Hirose, M Sato, M Aoki, H Kawaguchi, H Akimoto, Y Hatayama, F Komai, M Sohma, H Obara, M Suzuki, Y Takai, SU-E-J-40: Improving Uncertainty of Prostate Positioning by Using Implanted Fiducial Marker-Based Hybrid Evaluation Combined with KV Portal Imaging and CBCT for Prostate IMRT. Medical physics 2015; 42 (6): 3272-3272
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X Zhang, N Homma, Y Takai, K Ichiji, N Sugita, M Abe, M Yoshizawa, WE-AB-303-02: A Real-Time Homography-Based Algorithm for Markerless Deformable Lung Tumor Motion Tracking Using KV X-Ray Fluoroscopy. Medical physics 2015; 42 (6): 3656-3656
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Y. Hatayama, T. Nakamura, M. Suzuki, Y. Azami, T. Ono, H. Yamaguchi, Y. Hayashi, I. Tsukiyama, M. Hareyama, Y. Kikuchi, Y. Takai, Preliminary results of proton-beam therapy for stage III non-small-cell lung cancer Current Oncology. 2015; 22(5): e370-5
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Hatayama Y, Nakamura T, Suzuki M, Azami Y, Ono T, Yabuuchi T, Hayashi Y, Kimura K, Hirose K, Wada H, Hareyama M, Kikuchi Y, Takai Y. Clinical Outcomes and Prognostic Factors of High-Dose Proton Beam Therapy for Peripheral Stage I Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2015; pii: S1525-7304(15)00277-6.
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Aoki M, Hatayama Y, Kawaguchi H, Hirose K, Sato M, Akimoto H, Fujioka I, Ono S, Takai Y, Stereotactic body radiotherapy for lung metastases as oligo-recurrence: A single institutional study J Radiat Res 2016; 57:55-61
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Aoki M, Hatayama Y, Kawaguchi H, Hirose K, Sato M, Akimoto H, Fujioka I, Ono S, Tsushima E, Takai Y., Clinical outcome of stereotactic body radiotherapy for primary and oligometastatic lung tumors: a single institutional study with almost uniform dose with different five treatment schedules. Radiat Oncol. 2016; 20:11(1):5
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Aoki M, Hirose K, Sato M, Akimoto H, Kawaguchi H, Hatayama Y, Fujioka I, Tanaka M, Ono S, Takai Y., Prognostic impact of average iodine density assessed by dual-energy spectral imaging for predicting lung tumor recurrence after stereotactic body radiotherapy. J Radiat Res. 2016; pii: rrv100.
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Wada Y, Hirose K, Harada T, Sato M, Watanabe T, Anbai A, Hashimoto M, Takai Y. Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy. J Radiat Res. 2018; 59:122-128.
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Hirose K, Sato M, Hatayama Y, Kawaguchi H, Komai F, Sohma M, Obara H, Suzuki M, Tanaka M, Fujioka I, Ichise K, Takai Y, Aoki M., The potential failure risk of the cone-beam computed tomography-based planning target volume margin definition for prostate image-guided radiotherapy based on a prospective single-institutional hybrid analysis. Radiat Oncol. 2018 Jun 7;13(1):106. doi: 10.1186/s13014-018-1043-9.
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